New orleans (/ ɔːr ˈ l iː n z, ˈ ɔːr l (i) ə n z /, locally / ˈ ɔːr l ə n z /; french: la nouvelle-orléans [la nuvɛlɔʁleɑ̃] ()) is a consolidated city-parish located along the mississippi river in the southeastern region of the u.s. state of louisiana.with an estimated population of 393,292 in 2017, it is the most populous city in louisiana. a major port, new orleans is.